I am a postdoc researcher in mathematical neuroscience at the Inria Branch at the University of Montpellier, in the MathNeuro team. I part of the 2MDS project on the multiscale modeling of Dravet syndrome. |
Research interests
I study how changes at the level of individual neurons (ion channels mutation, activity-induced fluctuations in ion concentrations) affect their excitability, and the consequences on neuronal networks.
Tools:
L. Lemaire, M. Behbood, J. H. Schleimer and S. Schreiber. Integrate-and-fire neuron with potassium dynamics that capture switches in neuronal excitability class and firing regime, in preparation.
M. Behbood, L. Lemaire, J. H. Schleimer and S. Schreiber. The Na+/K+-ATPase generically enables deterministic bursting in class I neurons by shearing the spike-onset bifurcation structure, PLOS Computational Biology 20 (8), e1011751, 2024.
L. Lemaire, M. Desroches, M. Krupa and M. Mantegazza. Idealized multiple-timescale model of cortical spreading depolarization initiation and pre-epileptic hyperexcitability caused by NaV1.1/SCN1A, Journal of Mathematical Biology 86 (1), 92, 2023.
L. Lemaire, M. Desroches, M. Krupa, L. Pizzamiglio, P Scalmani and M. Mantegazza. Modeling NaV1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic migraine, PLOS Computational Biology 17 (7), e1009239, 2021. Code: https://modeldb.science/267047
O. Chever, S. Zerimech, P. Scalmani, L. Lemaire, A. Loucif, M Ayrault, M. Krupa, M. Desroches, F. Duprat, S. Cestèle and M. Mantegazza. Initiation of migraine-related cortical spreading depolarization by hyperactivity of GABAergic neurons and NaV1.1 channels, The Journal of Clinical Investigation 131 (21), e142203, 2021. Code: https://modeldb.science/267157
E. L. Carroll, R. Alderman, J. L. Bannister, M. Bérube, P. B. Best, L. Boren, C. S. Baker, C. Constantines, K. Findlay, R. Harcourt, L. Lemaire, P. J. Palsbøll, N. J. Patenaude, V. J. Rowntree, J. Seger, D. Steel, L. O. Valenzuela, M. Watson and O. E. Gaggiotti. Incorporating non-equilibrium dynamics into demographic history inferences of a migratory marine species, Heredity 122 (1), pp. 53-68, 2019.
L. Lemaire, F. Jay, I. Lee, K. Csilléry and M. Blum. Goodness-of-fit statistics for approximate Bayesian computation, arXiv, 2016.
Current | Postdoctoral researcher MathNeuro project-team Inria branch at the University of Montpellier, France |
2022-24 | Postdoctoral researcher Susanne Schreiber's Computational Neurophysiology group Institute for Theoretical Biology, Humboldt-Universität zu Berlin |
2018-21 | PhD in Applied MathematicsInria Sophia Antipolis - Méditerranée Research Centre, France Initiation of cortical spreading depolarization and pre-epileptic hyperactivity in a multiscale mathematical model of NaV1.1 mutations: Supervisors: Mathieu Desroches, Martin Krupa Reporters: Gemma Huguet, John Rinzel | ||||||||
2017-18 | MSc in Applied MathematicsUniversitat Politècnica de Catalunya (UPC), Barcelona Thesis: Mathematical modeling of metabolic symbiosis in tumour growth Supervisor: Tomás Alarcón | ||||||||
2016-17 | M1 (first year of master) in Applied Mathematics and Statistics Université Claude Bernard Lyon 1 | ||||||||
2013-16 |
BSc in Biology
Université Pierre-et-Marie-Curie (UPMC, Paris 6)
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2022 | ICMNS parallel session on Dynamical systems for neurological disorders |
2021 | MOMI workshop on industrial and applied mathematics |
2021 | Member of the Inria Sophia Antipolis PhD Seminars organizing committee |
2023 | Master course "Models of Neural Systems", 6h Bachelor course ”Quantitative biology”, 6h Humboldt-Universität zu Berlin |
2021 | Master course "Mathematical and computational models in neuroscience", 6h Sorbonne Université - Campus Pierre-et-Marie-Curie, Paris |
Inria branch at the University of Montpellier
Bât 5 - CC05 017, office 03/142
860 rue Saint-Priest
34095 Montpellier Cedex 5
France