I am a postdoc researcher in computational neuroscience in the Group for Neural Theory at École Normale Supérieure, Paris. I am part of the DyndriteSymphony ANR project coordinated by Boris Gutkin.

Publications

• L. Lemaire, M. Desroches, S. Rodrigues and F. Campillo. Depolarization block induction via slow Na_V1.1 inactivation in Dravet syndrome, Scientific Reports 15 (1), 32749, 2025. Code: github.com/louisianelemaire/Slow-NaV-inactivation-in-Dravet-syndrome.

• L. Preuss, J. H. Schleimer, L. Lemaire and S. Schreiber. Migraine mutations of the Na_V1.1 channel cause an excitability switch and energetically expensive spikes, in preparation.

• L. Lemaire, M. Behbood, J. H. Schleimer and S. Schreiber. Fitting bifurcation structure, not voltage traces: A biophysically inspired derivation of reduced neuron models exemplified by potassium dynamics, eLife 14 (reviewed preprint), 2025.

• M. Behbood, L. Lemaire, J. H. Schleimer and S. Schreiber. The Na⁺/K⁺-ATPase generically enables deterministic bursting in class I neurons by shearing the spike-onset bifurcation structure, PLOS Computational Biology 20 (8), e1011751, 2024.

• L. Lemaire, M. Desroches, M. Krupa and M. Mantegazza. Idealized multiple-timescale model of cortical spreading depolarization initiation and pre-epileptic hyperexcitability caused by Na_V1.1/SCN1A, Journal of Mathematical Biology 86 (1), 92, 2023.

• L. Lemaire, M. Desroches, M. Krupa, L. Pizzamiglio, P Scalmani and M. Mantegazza. Modeling Na_V1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic migraine, PLOS Computational Biology 17 (7), e1009239, 2021. Code: https://modeldb.science/267047.

• O. Chever, S. Zerimech, P. Scalmani, L. Lemaire, A. Loucif, M Ayrault, M. Krupa, M. Desroches, F. Duprat, S. Cestèle and M. Mantegazza. Initiation of migraine-related cortical spreading depolarization by hyperactivity of GABAergic neurons and Na_V1.1 channels, The Journal of Clinical Investigation 131 (21), e142203, 2021. Code: https://modeldb.science/267157.

• E. L. Carroll, R. Alderman, J. L. Bannister, M. Bérube, P. B. Best, L. Boren, C. S. Baker, C. Constantines, K. Findlay, R. Harcourt, L. Lemaire, P. J. Palsbøll, N. J. Patenaude, V. J. Rowntree, J. Seger, D. Steel, L. O. Valenzuela, M. Watson and O. E. Gaggiotti. Incorporating non-equilibrium dynamics into demographic history inferences of a migratory marine species, Heredity 122 (1), pp. 53-68, 2019.

• L. Lemaire, F. Jay, I. Lee, K. Csilléry and M. Blum. Goodness-of-fit statistics for approximate Bayesian computation, arXiv, 2016.

Presentations at international conferences

Talks

• - COUPLED 80 workshop
• - CNS*2025, "Computational strategies in epilepsy modelling and seizure control" workshop
• - 2025 International Conference on Mathematical Neuroscience
• - 2025 SIAM Conference on Applications of Dynamical Systems
• - 2024 International Conference on Mathematical Neuroscience
• - 2023 SIAM Conference on Dynamical Systems
• - International Conference on Spreading Depolarizations 2021
• - 2021 International Conference on Mathematical Neuroscience:
• - Virtual SMB 2021 Annual Meeting
• - 2021 SIAM Conference on Dynamical Systems
• - Dynamics Days Digital 2020:

Posters

• - European Dravet Syndrome Conference 2025
• - Bernstein Conference 2024
• - Bernstein Conference 2023
• - CNS*2023
• - 2019 International Conference on Mathematical Neuroscience

Positions

Current	Postdoctoral researcher Group for Neural Theory École Normale Supérieure, Paris, France
2024-26	Postdoctoral researcher MathNeuro project-team Inria branch at the University of Montpellier, France
2022-24	Postdoctoral researcher Susanne Schreiber's Computational Neurophysiology group Institute for Theoretical Biology, Humboldt-Universität zu Berlin

Education

2018-21	PhD in Applied Mathematics Inria Sophia Antipolis - Méditerranée Research Centre, France Initiation of cortical spreading depolarization and pre-epileptic hyperactivity in a multiscale mathematical model of NaV1.1 mutations: Supervisors: Mathieu Desroches, Martin Krupa Reporters: Gemma Huguet, John Rinzel
2017-18	MSc in Applied Mathematics Universitat Politècnica de Catalunya (UPC), Barcelona Thesis: Mathematical modeling of metabolic symbiosis in tumour growth Supervisor: Tomás Alarcón
2016-17	M1 (first year of master) in Applied Mathematics and Statistics Université Claude Bernard Lyon 1
2013-16	BSc in Biology Université Pierre-et-Marie-Curie (UPMC, Paris 6) 2016 Internship: Kalman filter for the tracking of bacterial motion Technische Universität Darmstadt, Germany Supervisor: Heinz Köppl 2015-16 Exchange year at the University of British Columbia (UBC), Vancouver 2015 Internship: Bayesian analysis for the demographic history of right whales University of St Andrews, Scotland Supervisor: Oscar Gaggiotti 2014 Internship: Goodness-of-fit algorithm for the R package Tools for Approximate Bayesian Computation Université Grenoble-Alpes, France Supervisor: Michael Blum

Event organisation

2024	Member of the organizing committee of the BCCN Berlin Postdoc Network Speaker Series
2022	ICMNS parallel session on Dynamical systems for neurological disorders
2021	Member of the local organizing committee for Dynamics Days Europe
2021	MOMI workshop on industrial and applied mathematics
2021	Member of the Inria Sophia Antipolis PhD Seminars organizing committee

Teaching

2026	Master course "Mathematical and computational models in neuroscience", 10h Sorbonne Université - Campus Pierre-et-Marie-Curie, Paris
2025	Master course "Mathematical and computational models in neuroscience", 10h Sorbonne Université - Campus Pierre-et-Marie-Curie, Paris
2023	Master course "Models of Neural Systems", 6h Bachelor course ”Quantitative biology”, 8h Humboldt-Universität zu Berlin
2021	Master course "Mathematical and computational models in neuroscience", 6h Sorbonne Université - Campus Pierre-et-Marie-Curie, Paris

louisiane.lemaire@ens.psl.eu

Group for Neural Theory (GNT)
29 rue d'Ulm
75005 Paris
France